Faculty, Staff and Student Publications
Publication Date
11-11-2023
Journal
Non-Coding RNA
Abstract
Long non-coding RNAs (lncRNAs) play pivotal roles in regulating immune responses, immune cell differentiation, activation, and inflammatory processes. In cancer, they are gaining prominence as potential therapeutic targets due to their ability to regulate immune checkpoint molecules and immune-related factors, suggesting avenues for bolstering anti-tumor immune responses. Here, we explore the mechanistic insights into lncRNA-mediated immune modulation, highlighting their impact on immunity. Additionally, we discuss their potential to enhance cancer immunotherapy, augmenting the effectiveness of immune checkpoint inhibitors and adoptive T cell therapies. LncRNAs as therapeutic targets hold the promise of revolutionizing cancer treatments, inspiring further research in this field with substantial clinical implications.
Keywords
lncRNA, ncRNA, cancer, immune response, biomarkers, immunotherapy
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Genomics Commons, Immunotherapy Commons, Medical Genetics Commons, Oncology Commons
Comments
PMID: 37987366