Role of Glucose Metabolic Reprogramming in Breast Cancer Progression and Drug Resistance

Authors

Pan Lei
Wenzhou Wang
Marisela Sheldon
Yutong Sun
Fan Yao
Li Ma

Publication Date

6-28-2023

Journal

Cancers

Abstract

The involvement of glucose metabolic reprogramming in breast cancer progression, metastasis, and therapy resistance has been increasingly appreciated. Studies in recent years have revealed molecular mechanisms by which glucose metabolic reprogramming regulates breast cancer. To date, despite a few metabolism-based drugs being tested in or en route to clinical trials, no drugs targeting glucose metabolism pathways have yet been approved to treat breast cancer. Here, we review the roles and mechanisms of action of glucose metabolic reprogramming in breast cancer progression and drug resistance. In addition, we summarize the currently available metabolic inhibitors targeting glucose metabolism and discuss the challenges and opportunities in targeting this pathway for breast cancer treatment.

Keywords

breast cancer, glucose metabolism, metastasis, drug resistance, Warburg effect, reverse Warburg effect, tumor microenvironment, metabolic inhibitor

Comments

PMID: 37444501