Pou4f1-Tbr1 Transcriptional Cascade Controls the Formation of Jam2-Expressing Retinal Ganglion Cells

Authors

Takae Kiyama
Halit Y Altay
Tudor C Badea
Chai-An Mao

Publication Date

1-1-2023

Journal

Frontiers in Ophthalmology

Abstract

More than 40 retinal ganglion cell (RGC) subtypes have been categorized in mouse based on their morphologies, functions, and molecular features. Among these diverse subtypes, orientation-selective Jam2-expressing RGCs (J-RGCs) has two unique morphologic characteristics: the ventral-facing dendritic arbor and the OFF-sublaminae stratified terminal dendrites in the inner plexiform layer. Previously, we have discovered that T-box transcription factor

Keywords

retinal ganglion cell, J-RGC, transcription regulation, CUT&Tag, Pou4f1, Tbr1, Jam2

Comments

Supplementary Material

Data Availability Statement

PMID: 38469155

DOI

10.3389/fopht.2023.1175568

PMID

38469155

PMCID

PMC10926710

PubMedCentral® Posted Date

May 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes