Comprehensive Analysis of the Prognostic Significance of the TRIM Family in the Context of TP53 Mutations in Cancers

Authors

Trung Vu
Annaliese Fowler
Nami McCarty

Publication Date

7-26-2023

Journal

Cancers

Abstract

The p53 protein is an important tumor suppressor, and TP53 mutations are frequently associated with poor prognosis in various cancers. Mutations in TP53 result in a loss of p53 function and enhanced expression of cell cycle genes, contributing to the development and progression of cancer. Meanwhile, several tripartite motif (TRIM) proteins are known to regulate cell growth and cell cycle transition. However, the prognostic values between TP53 and TRIM family genes in cancer are unknown. In this study, we analyzed the relationship between the

Comments

Supplementary Material

Data Availability Statement

PMID: 37568609

DOI

10.3390/cancers15153792

PMID

37568609

PMCID

PMC10417774

PubMedCentral® Posted Date

July 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes