Faculty, Staff and Student Publications

Publication Date

7-2-2024

Journal

Molecular Cancer Therapeutics

Abstract

Although patient-derived xenografts (PDX) are commonly used for preclinical modeling in cancer research, a standard approach to in vivo tumor growth analysis and assessment of antitumor activity is lacking, complicating the comparison of different studies and determination of whether a PDX experiment has produced evidence needed to consider a new therapy promising. We present consensus recommendations for assessment of PDX growth and antitumor activity, providing public access to a suite of tools for in vivo growth analyses. We expect that harmonizing PDX study design and analysis and assessing a suite of analytical tools will enhance information exchange and facilitate identification of promising novel therapies and biomarkers for guiding cancer therapy.

Keywords

Humans, Animals, Xenograft Model Antitumor Assays, Neoplasms, National Cancer Institute (U.S.), United States, Mice, Antineoplastic Agents, Consensus

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