Outcomes After Definitive Treatment for Cutaneous Angiosarcomas of the Face and Scalp: Reevaluating the Role of Surgery and Radiation Therapy

Authors

Alison K Yoder
Ahsan S Farooqi
Cort Wernz
Aparna Subramaniam
Vinod Ravi
Ryan Goepfert
Erich M Sturgis
Devarati Mitra
Andrew J Bishop
B Ashleigh Guadagnolo

Publication Date

8-1-2023

Journal

Head & Neck

Abstract

INTRODUCTION: We investigated outcomes and prognostic factors for patients treated for cutaneous angiosarcoma (CA).

METHODS: We conducted a retrospective review of patients treated for CA of the face and scalp from 1962 to 2019. All received definitive treatment with surgery, radiation (RT), or a combination (S-XRT). The Kaplan-Meier method was used to estimate outcomes. Multivariable analyses were conducted using the Cox proportional hazards model.

RESULTS: For the 143 patients evaluated median follow-up was 33 months. Five-year LC was 51% and worse in patients with tumors >5 cm, multifocal tumors, those treated pre-2000, and with single modality therapy (SMT). These remained associated with worse LC on multivariable analysis. The 5-year disease-specific survival (DSS) for the cohort was 56%. Tumor size >5 cm, non-scalp primary site, treatment pre-2000, and SMT were associated with worse DSS.

CONCLUSION: Large or multifocal tumors are negative prognostic factors in patients with head and neck CA. S-XRT improved outcomes.

Keywords

Humans, Hemangiosarcoma, Skin Neoplasms, Retrospective Studies, Proportional Hazards Models, Combined Modality Therapy, Prognosis, Head and Neck Neoplasms

Comments

Data Availability Statement

PMID: 37272774

DOI

10.1002/hed.27418

PMID

37272774

PMCID

PMC11350586

PubMedCentral® Posted Date

August 2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes