Colorectal Surveillance Outcomes From an Institutional Longitudinal Cohort of Lynch Syndrome Carriers

Authors

Gabriel Del Carmen
Laura Reyes-Uribe
Daniel Goyco
Kyera Evans
Charles M Bowen
Jennifer L Kinnison
Valerie O Sepeda
Diane M Weber
Julie Moskowitz
Maureen E Mork
Selvi Thirumurthi
Patrick M Lynch
Miguel A Rodriguez-Bigas
Melissa W Taggart
Y Nancy You
Eduardo Vilar

Publication Date

1-1-2023

Journal

Frontiers in Oncology

Abstract

OBJECTIVE: Lynch Syndrome (LS) carriers have a significantly increased risk of developing colorectal cancer (CRC) during their lifetimes. Further stratification of this patient population may help in identifying additional risk factors that predispose to colorectal carcinogenesis. In most LS patients CRC may arise from adenomas, although an alternative non-polypoid carcinogenesis pathway has been proposed for

DESIGN: We collected demographics, genetic, colonoscopy, and pathology results from a total of 163 LS carriers who obtained regular screening care at MD Anderson Cancer Center. Data were extracted from the electronic health records into a REDCap database for analysis. Logistic regressions were performed to measure the association between MMR variants and the likelihood of adenomas, advanced adenomas, and CRC. Then, we analyzed the cumulative incidences of these outcomes for the first 36 months following enrollment using Kaplan-Meier incidence curves, and Cox proportional hazard regressions.

RESULTS: On multivariate analysis, age (≥45 years old) was associated with an increased risk of developing adenomas (

CONCLUSION: Screening recommendations for CRC in LS patients should be based on specific MMR variants and should also be tailored to consider patient demographics.

Keywords

lynch, colorectal < cancer type, surveillance, colonoscopy, premalignancies

Comments

Supplementary Materials

Data Availability Statement

PMID: 37168379