Faculty, Staff and Student Publications
Publication Date
6-2-2023
Journal
Nature Communications
Abstract
We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare "clumping-and-thresholding" (PRSice2) and LD-based (LDPred2) methods to construct PRSs from each of multiple GWAS, as well as multi-PRS approaches that sum PRSs with and without weights, including PRS-CSx. We use datasets from the MGB Biobank, TOPMed study, UK biobank, and from All of Us to train, assess, and validate PRSs in groups defined by self-reported race/ethnic background (Asian, Black, Hispanic/Latino, and White). For both SBP and DBP, the PRS-CSx based PRS, constructed as a weighted sum of PRSs developed from multiple independent GWAS, perform best across all race/ethnic backgrounds. Stratified analysis in All of Us shows that PRSs are better predictive of BP in females compared to males, individuals without obesity, and middle-aged (40-60 years) compared to older and younger individuals.
Keywords
Male, Female, Humans, Blood Pressure, Population Health, Risk Factors, Multifactorial Inheritance, Ethnicity, Genome-Wide Association Study, Genetic Predisposition to Disease
DOI
10.1038/s41467-023-38990-9
PMID
37268629
PMCID
PMC10238525
PubMedCentral® Posted Date
June 2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Community Health and Preventive Medicine Commons, Medical Sciences Commons, Medicine and Health Commons, Oncology Commons, Race and Ethnicity Commons
Comments
Supplementary Material
Data Availability Statement
PMID: 37268629