Faculty, Staff and Student Publications

Publication Date

3-14-2023

Journal

Nature Communications

DOI

10.1038/s41467-023-36997-w

PMID

36918541

PMCID

PMC10015012

PubMedCentral® Posted Date

March 2023

PubMedCentral® Full Text Version

Post-print

Abstract

The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.

Keywords

Humans, Cardiovascular Diseases, Atrioventricular Block, Genome-Wide Association Study, Risk Factors, Arrhythmias, Cardiac, Electrocardiography, Biomarkers

Published Open-Access

yes

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