
Faculty, Staff and Student Publications
Publication Date
3-1-2023
Journal
Nature Chemical Biology
Abstract
We report the engineering and selection of two synthetic proteins-FSR16m and FSR22-for the possible treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. FSR16m and FSR22 are trimeric proteins composed of DARPin SR16m or SR22 fused with a T4 foldon. Despite selection by a spike protein from a now historical SARS-CoV-2 strain, FSR16m and FSR22 exhibit broad-spectrum neutralization of SARS-CoV-2 strains, inhibiting authentic B.1.351, B.1.617.2 and BA.1.1 viruses, with respective IC
Keywords
Animals, Mice, Humans, SARS-CoV-2, Designed Ankyrin Repeat Proteins, COVID-19, Mice, Transgenic
DOI
10.1038/s41589-022-01193-2
PMID
36411391
PMCID
PMC10294592
PubMedCentral® Posted Date
March 2024
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes

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