Novel Potential Targets for Function-Promoting Therapies: Orphan Nuclear Receptors, Anti-inflammatory Drugs, Troponin Activators, Mas Receptor Agonists, and Urolithin A

Authors

Waly Dioh
Vihang Narkar
Anurag Singh
Fady Malik
Luigi Ferrucci
Cendrine Tourette
Jean Mariani
Rob van Maanen
Roger A Fielding

Publication Date

6-16-2023

Journal

The Journals of Gerontology: Series A

Abstract

In recent years, several new classes of therapies have been investigated with their potential for restoring or improving physical functioning in older adults. These have included Mas receptor agonists, regulators of mitophagy, skeletal muscle troponin activators, anti-inflammatory compounds, and targets of orphan nuclear receptors. The present article summarizes recent developments of the function-promoting effects of these exciting new compounds and shares relevant preclinical and clinical data related to their safety and efficacy. The development of novel compounds in this area is expanding and likely will need the advent of a new treatment paradigm for age-associated mobility loss and disability.

Keywords

Orphan Nuclear Receptors, Anti-Inflammatory Agents, Mas receptor, Mitophagy regulators, Orphan nuclear receptors, Physical function, Skeletal muscle dysfunction, Troponin activators

Comments

PMID: 37325960

DOI

10.1093/gerona/glad072

PMID

37325960

PMCID

PMC10272986

PubMedCentral® Posted Date

June 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes