Faculty, Staff and Student Publications
Publication Date
6-16-2023
Journal
The Journals of Gerontology: Series A
Abstract
In recent years, several new classes of therapies have been investigated with their potential for restoring or improving physical functioning in older adults. These have included Mas receptor agonists, regulators of mitophagy, skeletal muscle troponin activators, anti-inflammatory compounds, and targets of orphan nuclear receptors. The present article summarizes recent developments of the function-promoting effects of these exciting new compounds and shares relevant preclinical and clinical data related to their safety and efficacy. The development of novel compounds in this area is expanding and likely will need the advent of a new treatment paradigm for age-associated mobility loss and disability.
Keywords
Orphan Nuclear Receptors, Anti-Inflammatory Agents, Mas receptor, Mitophagy regulators, Orphan nuclear receptors, Physical function, Skeletal muscle dysfunction, Troponin activators
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons
Comments
PMID: 37325960