Estrogen-Related Receptor Gamma Gene Therapy Promotes Therapeutic Angiogenesis and Muscle Recovery in Preclinical Model of PAD

Authors

Danesh H Sopariwala
Andrea S Rios
Addison Saley
Ashok Kumar
Vihang A Narkar

Publication Date

8-15-2023

Journal

Journal of the American Heart Association

Abstract

Background Peripheral arterial disease and critical limb ischemia are cardiovascular complications associated with vascular insufficiency, oxidative metabolic dysfunction, and myopathy in the limbs. Estrogen-related receptor gamma (ERRγ) has emerged as a dual regulator of paracrine angiogenesis and oxidative metabolism through transgenic mouse studies. Here our objective was to investigate whether postischemic intramuscular targeting of ERRγ via gene therapy promotes ischemic recovery in a preclinical model of peripheral arterial disease/critical limb ischemia. Methods and Results Adeno-associated virus 9 (AAV9)

Keywords

Mice, Animals, Succinate Dehydrogenase, Chronic Limb-Threatening Ischemia, Neovascularization, Physiologic, Muscle, Skeletal, Genetic Therapy, Mice, Transgenic, Peripheral Arterial Disease, Ischemia, Estrogens, Hindlimb, Mice, Inbred C57BL, Disease Models, Animal

Comments

Supplementary Materials

Data Availability Statement

PMID: 37548153