NMDA Receptor Subunit NMR-2 Regulates Pathogen-Induced Immune Responses via the Nervous System in C. elegans

Authors

• Benson Otarigho
• Jonathan Lalsiamthara
• Alejandro Aballay

Language

English

Publication Date

6-2-2026

DOI

10.64898/2026.05.29.728750

PMID

42282556

PMCID

PMC13252404

PubMedCentral® Posted Date

6-2-2026

PubMedCentral® Full Text Version

Post-print

Abstract

Neural control of innate immunity must balance restraint of basal immune activity with rapid activation upon pathogen encounter. Glutamate, the primary excitatory neurotransmitter in the nervous system, has been implicated in several neurological disorders associated with inflammation, suggesting a potential link to immune regulation. However, how glutamatergic signaling contributes to immune balance remains unknown. Here, we demonstrated that the NMDA-type ionotropic glutamate receptor subunit NMR-2, a component of the NMDA receptor complex, acts in the

Published Open-Access

yes

Recommended Citation

Benson Otarigho, Jonathan Lalsiamthara, and Alejandro Aballay, "NMDA Receptor Subunit NMR-2 Regulates Pathogen-Induced Immune Responses via the Nervous System in C. elegans" (2026). Faculty, Staff and Student Publications. 1761.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/1761