Microcalcification Crystallography as a Potential Marker of DCIS Recurrence

Authors

Zoey A Miller
Arielle Mueller
TaeBeom Kim
Jennifer F Jolivert
Ray Z Ma
Sahil Muthuswami
April Park
Derek B McMahon
Kevin T Nead
Ryan M Carey
Robert J Lee

Publication Date

12-26-2023

Journal

Cell Reports

Abstract

Head and neck squamous cell carcinomas (HNSCCs) have high mortality and significant treatment-related morbidity. It is vital to discover effective, minimally invasive therapies that improve survival and quality of life. Bitter taste receptors (T2Rs) are expressed in HNSCCs, and T2R activation can induce apoptosis. Lidocaine is a local anesthetic that also activates bitter taste receptor 14 (T2R14). Lidocaine has some anti-cancer effects, but the mechanisms are unclear. Here, we find that lidocaine causes intracellular Ca

Keywords

Humans, Taste, Receptors, G-Protein-Coupled, Squamous Cell Carcinoma of Head and Neck, Lidocaine, Papillomavirus Infections, Quality of Life, Head and Neck Neoplasms, Apoptosis

Comments

Supplementary Materials

Data Availability Statement

PMID: 37995679