Effects of Antiresorptive Medications on Tooth Root Formation and Tooth Eruption in Paediatric Patients

Authors

Yuki Arai
Jeryl D English
Noriaki Ono
Wanida Ono

Publication Date

12-1-2023

Journal

Orthodontics & Craniofacial Research

Abstract

Tooth eruption is a pivotal milestone for children's growth and development. This process involves with the formation of the tooth root, the periodontal ligament (PDL) and the alveolar bone, as the tooth crown penetrates the bone and gingiva to enter the oral cavity. This review aims to outline current knowledge of the adverse dental effects of antiresorptive medications. Recently, paediatric indications for antiresorptive medications, such as bisphosphonates (BPs), have emerged, and these agents are increasingly used in children and adolescents to cure pathological bone resorption associated with bone diseases and cancers. Since tooth eruption is accompanied by osteoclastic bone resorption, it is expected that the administration of antiresorptive medications during this period affects tooth development. Indeed, several articles studying human patient cohorts and animal models report the dental defects associated with the use of these antiresorptive medications. This review shows the summary of the possible factors related to tooth eruption and introduces the future research direction to understand the mechanisms underlying the dental defects caused by antiresorptive medications.

Keywords

Animals, Humans, Child, Adolescent, Tooth Eruption, Tooth Root, Periodontal Ligament, Diphosphonates, Bone Resorption, antiresorptives, tooth eruption, tooth formation, tooth root

Comments

Data Availability Statement

PMID: 36714970

DOI

10.1111/ocr.12637

PMID

36714970

PMCID

PMC10864015

PubMedCentral® Posted Date

February 2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes