Anatomical Validation of Automatic Respiratory Motion Correction for Coronary 18F-Sodium Fluoride Positron Emission Tomography by Expert Measurements From Four-Dimensional Computed Tomography

Authors

Martin Lyngby Lassen
Evangelos Tzolos
Tinsu Pan
Jacek Kwiecinski
Sebastien Cadet
Damini Dey
Daniel Berman
Piotr Slomka

Publication Date

11-1-2022

Journal

Medical Physics

Abstract

BACKGROUND: Respiratory motion correction is of importance in studies of coronary plaques employing

PURPOSE: To investigate the accuracy of the motion correction employed in a software (FusionQuant) used for evaluation of

METHODS: This study included 23 patients who undertook thoracic PET scans for the assessment of coronary plaques using

RESULTS: In total, 19 coronary plaques were identified in 16 patients. No statistical differences were observed for the maximum respiratory motion observed in x, y, and the 3D motion fields (magnitude and direction) between the CT and PET (X direction: 4D CT = 2.5 ± 1.5 mm, PET = 2.4 ± 3.2 mm; Y direction: 4D CT = 2.3 ± 1.9 mm, PET = 0.7 ± 2.9 mm, 3D motion: 4D CT = 6.6 ± 3.1 mm, PET = 5.7 ± 2.6 mm, all p ≥ 0.05). Significant differences in respiratory motion were observed in the systems' Z direction: 4D CT = 4.9 ± 3.4 mm, PET = 2.3 ± 3.2 mm, p = 0.04. Significantly improved SNR is reported for the motion corrected images compared to the end-expiratory phase images (end-expiratory phase = 6.8±4.8, motion corrected = 12.2±4.5, p = 0.001).

CONCLUSION: Similar respiratory motion was observed in two directions and 3D for coronary plaques on 4D CT as detected by automatic respiratory motion correction of coronary PET using FusionQuant. The respiratory motion correction technique significantly improved the SNR in the images.

Keywords

Humans, Four-Dimensional Computed Tomography, Sodium Fluoride, Sodium, Positron-Emission Tomography

Comments

Supplementary Materials

PMID: 35766454