Age-Associated Spinal Stenosis in the Turquoise Killifish

Authors

Su-Hyeon Cho
Seongsin Lee
Jae-Il Park
Yoon La Yang
Song-Rae Kim
Juhee Ahn
Hoibin Jeong
Hye-Yeon Jung
Nayoung Gwak
Kil-Nam Kim
Yumi Kim

Publication Date

10-20-2023

Journal

iScience

Abstract

Aging triggers spinal degeneration, including common spinal stenosis, which causes back and leg pain in older individuals, significantly impacting their quality of life. Here, we explored aging traits in turquoise killifish spines, potentially offering a model for age-linked spinal stenosis in humans. Aged turquoise killifish exhibited body shape deformation and increased vertebral collapse, which was further accelerated by spawning. High-resolution CT scans revealed suppressed cortical bone thickness and hemal arch area in vertebrae due to spawning, and osteophyte formation was observed in both aged and breeding fish populations. Scale mineralization mirrored these changes, increasing with age but being suppressed by spawning. The expression of

Comments

Supplementary Materials

Data Availability Statement

PMID: 37810235