Gankyrin-Mediated Interaction Between Cancer Cells and Tumor-Associated Macrophages Facilitates Prostate Cancer Progression and Androgen Deprivation Therapy Resistance

Authors

Guang Peng
Chao Wang
Hongru Wang
Min Qu
Keqin Dong
Yongwei Yu
Yuquan Jiang
Sishun Gan
Xu Gao

Publication Date

1-1-2023

Journal

OncoImmunology

Abstract

Increasing evidence reveals that the interaction between tumor cells and tumor-associated macrophages (TAMs) facilitates the progression of prostate cancer, but the related mechanisms remained unclear. This study determined how gankyrin, a component of the 19S regulatory complex of the 26S proteasome, regulates the progression and androgen deprivation therapy (ADT) resistance of prostate cancer through tumor cell-TAM interactions.

Keywords

Humans, Male, Androgen Antagonists, Androgens, HMGB1 Protein, Interleukin-6, Prostatic Neoplasms, Tumor-Associated Macrophages, Proteasome Endopeptidase Complex, Tumor-associated macrophages, gankyrin, prostate cancer, androgen deprivation therapy, tumor progression

Comments

Supplementary Material

Data Availability Statement

PMID: 36776524

DOI

10.1080/2162402X.2023.2173422

PMID

36776524

PMCID

PMC9908295

PubMedCentral® Posted Date

February 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes