The Hyphal-Specific Toxin Candidalysin Promotes Fungal Gut Commensalism

Authors

Shen-Huan Liang
Shabnam Sircaik
Joseph Dainis
Pallavi Kakade
Swathi Penumutchu
Liam D McDonough
Ying-Han Chen
Corey Frazer
Tim B Schille
Stefanie Allert
Osama Elshafee
Maria Hänel
Selene Mogavero
Shipra Vaishnava
Ken Cadwell
Peter Belenky
J Christian Perez
Bernhard Hube
Iuliana V Ene
Richard J Bennett

Publication Date

3-1-2024

Journal

Nature

Abstract

The fungus Candida albicans frequently colonizes the human gastrointestinal tract, from which it can disseminate to cause systemic disease. This polymorphic species can transition between growing as single-celled yeast and as multicellular hyphae to adapt to its environment. The current dogma of C. albicans commensalism is that the yeast form is optimal for gut colonization, whereas hyphal cells are detrimental to colonization but critical for virulence

Keywords

Animals, Female, Humans, Male, Mice, Bacteria, Candida albicans, Fungal Proteins, Gastrointestinal Microbiome, Hyphae, Immunoglobulin A, Intestines, Mycotoxins, Symbiosis, Virulence

Comments

Supplementary Materials

Data Availability Statement

PMID: 38448595