Faculty, Staff and Student Publications

Publication Date

3-1-2024

Journal

Nature

Abstract

The fungus Candida albicans frequently colonizes the human gastrointestinal tract, from which it can disseminate to cause systemic disease. This polymorphic species can transition between growing as single-celled yeast and as multicellular hyphae to adapt to its environment. The current dogma of C. albicans commensalism is that the yeast form is optimal for gut colonization, whereas hyphal cells are detrimental to colonization but critical for virulence

Keywords

Animals, Female, Humans, Male, Mice, Bacteria, Candida albicans, Fungal Proteins, Gastrointestinal Microbiome, Hyphae, Immunoglobulin A, Intestines, Mycotoxins, Symbiosis, Virulence

DOI

10.1038/s41586-024-07142-4

PMID

38448595

PMCID

PMC11230112

PubMedCentral® Posted Date

September 2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

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