Artificial Intelligence-Based Radiotherapy Contouring and Planning to Improve Global Access to Cancer Care

Authors

Laurence E Court
Ajay Aggarwal
Anuja Jhingran
Komeela Naidoo
Tucker Netherton
Adenike Olanrewaju
Christine Peterson
Jeannette Parkes
Hannah Simonds
Christoph Trauernicht
Lifei Zhang
Beth M Beadle
Radiation Planning Assistant Consortium Collaborators, Affiliations Expand

Publication Date

3-1-2024

Journal

JCO Global Oncology

Abstract

PURPOSE: Increased automation has been identified as one approach to improving global cancer care. The Radiation Planning Assistant (RPA) is a web-based tool offering automated radiotherapy (RT) contouring and planning to low-resource clinics. In this study, the RPA workflow and clinical acceptability were assessed by physicians around the world.

METHODS: The RPA output for 75 cases was reviewed by at least three physicians; 31 radiation oncologists at 16 institutions in six countries on five continents reviewed RPA contours and plans for clinical acceptability using a 5-point Likert scale.

RESULTS: For cervical cancer, RPA plans using bony landmarks were scored as usable as-is in 81% (with minor edits 93%); using soft tissue contours, plans were scored as usable as-is in 79% (with minor edits 96%). For postmastectomy breast cancer, RPA plans were scored as usable as-is in 44% (with minor edits 91%). For whole-brain treatment, RPA plans were scored as usable as-is in 67% (with minor edits 99%). For head/neck cancer, the normal tissue autocontours were acceptable as-is in 89% (with minor edits 97%). The clinical target volumes (CTVs) were acceptable as-is in 40% (with minor edits 93%). The volumetric-modulated arc therapy (VMAT) plans were acceptable as-is in 87% (with minor edits 96%). For cervical cancer, the normal tissue autocontours were acceptable as-is in 92% (with minor edits 99%). The CTVs for cervical cancer were scored as acceptable as-is in 83% (with minor edits 92%). The VMAT plans for cervical cancer were acceptable as-is in 99% (with minor edits 100%).

CONCLUSION: The RPA, a web-based tool designed to improve access to high-quality RT in low-resource settings, has high rates of clinical acceptability by practicing clinicians around the world. It has significant potential for successful implementation in low-resource clinics.

Keywords

Female, Humans, Breast Neoplasms, Artificial Intelligence, Uterine Cervical Neoplasms, Radiotherapy Planning, Computer-Assisted, Mastectomy

Comments

This article has been corrected. See JCO Glob Oncol. 2024; 10: e2400124.

PMID: 38484191