The Combination of Tumor Mutational Burden and T-Cell Receptor Repertoire Predicts the Response to Immunotherapy in Patients With Advanced Non-Small Cell Lung Cancer

Authors

Yalun Li
Liyan Ji
Yingqian Zhang
Jiexin Zhang
Alexandre Reuben
Hao Zeng
Qin Huang
Qi Wei
Sihan Tan
Xuefeng Xia
Weimin Li
Jianjun Zhang
Panwen Tian

Publication Date

6-1-2024

Journal

MedComm

Abstract

Tumor mutational burden (TMB) and T-cell receptor (TCR) might predict the response to immunotherapy in patients with non-small cell lung cancer (NSCLC). However, the predictive value of the combination of TMB and TCR was not clear. Targeted DNA and TCR sequencing were performed on tumor biopsy specimens. We combined TMB and TCR diversity into a TMB-and-TCR (TMR) score using logistic regression. In total, 38 patients with advanced NSCLC were divided into a discovery set (

Keywords

advanced non–small cell lung cancer, clonality, immunotherapy, T‐cell receptors, tumor mutational burden

Comments

Supplementary Material

Data Availability Statement

PMID: 38840771

DOI

10.1002/mco2.604

PMID

38840771

PMCID

PMC11151154

PubMedCentral® Posted Date

June 2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes