Faculty, Staff and Student Publications
Publication Date
11-1-2022
Journal
Nature Methods
Abstract
Neoantigens are the key targets of antitumor immune responses from cytotoxic T cells and play a critical role in affecting tumor progressions and immunotherapy treatment responses. However, little is known about how the interaction between neoantigens and T cells ultimately affects the evolution of cancerous masses. Here, we develop a hierarchical Bayesian model, named neoantigen-T cell interaction estimation (netie) to infer the history of neoantigen-CD8
Keywords
Humans, Antigens, Neoplasm, Bayes Theorem, Immunotherapy, Neoplasms, Cell Communication
DOI
10.1038/s41592-022-01644-7
PMID
36303017
PMCID
PMC10083098
PubMedCentral® Posted Date
April 2023
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons