Netie: Inferring the Evolution of Neoantigen-T Cell Interactions in Tumors

Authors

Tianshi Lu
Seongoh Park
Yi Han
Yunguan Wang
Shawna Marie Hubert
P Andy Futreal
Ignacio Wistuba
John V Heymach
Alexandre Reuben
Jianjun Zhang
Tao Wang

Publication Date

11-1-2022

Journal

Nature Methods

Abstract

Neoantigens are the key targets of antitumor immune responses from cytotoxic T cells and play a critical role in affecting tumor progressions and immunotherapy treatment responses. However, little is known about how the interaction between neoantigens and T cells ultimately affects the evolution of cancerous masses. Here, we develop a hierarchical Bayesian model, named neoantigen-T cell interaction estimation (netie) to infer the history of neoantigen-CD8

Keywords

Humans, Antigens, Neoplasm, Bayes Theorem, Immunotherapy, Neoplasms, Cell Communication

Comments

Supplementary Material

Data Availability Statement

PMID: 36303017

DOI

10.1038/s41592-022-01644-7

PMID

36303017

PMCID

PMC10083098

PubMedCentral® Posted Date

April 2023

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes