Improved Humoral Immunity and Protection against Influenza Virus Infection with a 3d Porous Biomaterial Vaccine

Authors

Hiromi Miwa
Olivia Q Antao
Kindra M Kelly-Scumpia
Sevana Baghdasarian
Daniel P Mayer
Lily Shang
Gina M Sanchez
Maani M Archang
Philip O Scumpia
Jason S Weinstein
Dino Di Carlo

Publication Date

11-1-2023

Journal

Advanced Science

Abstract

New vaccine platforms that activate humoral immunity and generate neutralizing antibodies are required to combat emerging pathogens, including influenza virus. A slurry of antigen-loaded hydrogel microparticles that anneal to form a porous scaffold with high surface area for antigen uptake by infiltrating immune cells as the biomaterial degrades is demonstrated to enhance humoral immunity. Antigen-loaded-microgels elicited a robust cellular humoral immune response, with increased CD4

Keywords

Animals, Mice, Humans, Immunity, Humoral, Influenza, Human, Porosity, Influenza Vaccines, Antibodies, Viral, Orthomyxoviridae, Orthomyxoviridae Infections, Antigens

DOI

10.1002/advs.202302248

PMID

37750461

PMCID

PMC10625058

PubMedCentral® Posted Date

September 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes