Improved Humoral Immunity and Protection against Influenza Virus Infection with a 3d Porous Biomaterial Vaccine

Authors

Hiromi Miwa
Olivia Q Antao
Kindra M Kelly-Scumpia
Sevana Baghdasarian
Daniel P Mayer
Lily Shang
Gina M Sanchez
Maani M Archang
Philip O Scumpia
Jason S Weinstein
Dino Di Carlo

Publication Date

11-1-2023

Journal

Advanced Science

Abstract

New vaccine platforms that activate humoral immunity and generate neutralizing antibodies are required to combat emerging pathogens, including influenza virus. A slurry of antigen-loaded hydrogel microparticles that anneal to form a porous scaffold with high surface area for antigen uptake by infiltrating immune cells as the biomaterial degrades is demonstrated to enhance humoral immunity. Antigen-loaded-microgels elicited a robust cellular humoral immune response, with increased CD4

Keywords

Animals, Mice, Humans, Immunity, Humoral, Influenza, Human, Porosity, Influenza Vaccines, Antibodies, Viral, Orthomyxoviridae, Orthomyxoviridae Infections, Antigens

Comments

Supplementary Materials

Data Availability Statement

PMID: 37750461