RAD21 Promotes Oncogenesis and Lethal Progression of Prostate Cancer

Authors

Xiaofeng A Su
Konrad H Stopsack
Daniel R Schmidt
Duanduan Ma
Zhe Li
Paul A Scheet
Kathryn L Penney
Tamara L Lotan
Wassim Abida
Elise G DeArment
Kate Lu
Thomas Janas
Sofia Hu
Matthew G Vander Heiden
Massimo Loda
Monica Boselli
Angelika Amon
Lorelei A Mucci

Publication Date

9-3-2024

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abstract

Higher levels of aneuploidy, characterized by imbalanced chromosome numbers, are associated with lethal progression in prostate cancer. However, how aneuploidy contributes to prostate cancer aggressiveness remains poorly understood. In this study, we assessed in patients which genes on chromosome 8q, one of the most frequently gained chromosome arms in prostate tumors, were most strongly associated with long-term risk of cancer progression to metastases and death from prostate cancer (lethal disease) in 403 patients and found the strongest candidate was cohesin subunit gene,

Keywords

Humans, Male, Prostatic Neoplasms, DNA-Binding Proteins, Cell Cycle Proteins, Aneuploidy, Carcinogenesis, Disease Progression, Nuclear Proteins, Oncogene Proteins, Fusion, Chromosomes, Human, Pair 8, Gene Expression Regulation, Neoplastic, DNA Damage, prostate cancer, RAD21, DNA damage, organoid, clinical outcomes

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Associated Data

PMID: 39190349