The In Vitro Activity of Delafloxacin and Comparator Agents Against Bacterial Pathogens Isolated From Patients With Cancer

Authors

Bahgat Gerges
Kenneth Rolston
Samuel A Shelburne
Joel Rosenblatt
Randall Prince
Issam Raad

Publication Date

4-1-2023

Journal

JAC-Antimicrobial Resistance

Abstract

BACKGROUND: Fluoroquinolones are used for infection prevention in high-risk patients with haematological malignancies. Fluoroquinolones are active against many Gram-negative bacilli (GNB) but are less active against Gram-positive organisms. We evaluated the

METHODS: Antimicrobial susceptibility testing and time-kill studies were performed using CLSI-approved methodology and interpretive criteria for 350 Gram-positive organisms and 210 GNB that had been recently isolated from patients with cancer.

RESULTS: Delafloxacin was more active than ciprofloxacin and levofloxacin against

CONCLUSIONS: Delafloxacin is more active than ciprofloxacin and levofloxacin against

Comments

PMID: 36994231