Correlations Between Peripheral Levels of Inflammatory Mediators and Frontolimbic Structures in Bipolar Disorder: An Exploratory Analysis

Authors

Satyajit Mohite
Haitham Salem
Thiago Cordeiro
Jonika Tannous
Benson Mwangi
Sudhakar Selvaraj
Jair C Soares
Marsal Sanches
Antonio L Teixeira

Publication Date

10-1-2022

Journal

CNS Spectrums

Abstract

BACKGROUND: Altered peripheral immune/inflammatory system and brain volumetric changes have been implicated in the pathophysiology of bipolar disorder (BD). This study aimed to evaluate how peripheral levels of cytokines are related to volumetric brain changes in euthymic patients with BD.

METHODS: Euthymic patients with BD (n = 21) and healthy controls (n = 22) were enrolled in this exploratory study. Blood samples were collected on the same day of clinical assessment and neuroimaging. Cytokines were measured through cytometric bead array method. Neuroimaging data were acquired using a sagittal three-dimensional magnetic resonance imaging T1-weighted fast field echo sequence and was processed using FreeSurfer.

RESULTS: Compared to controls, BD patients had significantly lower volumes in the cingulate, medial-orbitofrontal (MOF) and parahippocampal regions. We found a negative correlation between right MOF volume and interferon-gamma levels (

CONCLUSION: Our results support the involvement of inflammatory pathways in structural brain changes in BD.

Keywords

Humans, Bipolar Disorder, Gray Matter, Interleukin-10, Inflammation Mediators, Interferon-gamma, Magnetic Resonance Imaging, Brain, Bipolar disorder, neuroinflammation, neuroimaging, gray matter, prefrontal cortex, accelerated aging

Comments

PMID: 34121653