Faculty, Staff and Student Publications

Publication Date

9-4-2023

Journal

International Journal of Gynecological Cancer

Abstract

Compared with high-grade serous carcinoma, low-grade serous carcinoma of the ovary or peritoneum is a less frequent epithelial ovarian cancer type that is poorly sensitive to chemotherapy and affects younger women, many of whom endure years of ineffective treatments and poor quality of life. The pathogenesis of this disease and its management remain incompletely understood. However, recent advances in the molecular characterization of the disease and identification of novel targeted therapies with activity in low-grade serous carcinoma offer the promise of improved outcomes. To update clinicians regarding recent scientific and clinical trial advancements and discuss unanswered questions related to low-grade serous carcinoma diagnosis and treatment, a panel of experts convened for a workshop in October 2022 to develop a consensus document addressing pathology, translational research, epidemiology and risk, clinical management, and ongoing research. In addition, the patient perspective was discussed. The recommendations developed by this expert panel-presented in this consensus document-will guide practitioners in all settings regarding the clinical management of women with low-grade serous carcinoma and discuss future opportunities to improve research and patient care.

Keywords

Humans, Female, Consensus, Quality of Life, Peritoneal Neoplasms, Carcinoma, Ovarian Epithelial, Cystadenocarcinoma, Papillary, Cystadenocarcinoma, Serous, Ovarian Neoplasms, Ovarian Cancer; Cystadenocarcinoma, Serous; Pathology

Comments

PMID: 37591609

DOI

10.1136/ijgc-2023-004610

PMID

37591609

PMCID

PMC10511962

PubMedCentral® Posted Date

August 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

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