New Horizons in Hyperpolarized13C MRI

Authors

Myriam M Chaumeil
James A Bankson
Kevin M Brindle
Shdema Epstein
Ferdia A Gallagher
Martin Grashei
Caroline Guglielmetti
Joshua D Kaggie
Kayvan R Keshari
Stephan Knecht
Christoffer Laustsen
Andreas B Schmidt
Daniel Vigneron
Yi-Fen Yen
Franz Schilling

Publication Date

4-1-2024

Journal

Molecular Imaging and Biology

Abstract

Hyperpolarization techniques significantly enhance the sensitivity of magnetic resonance (MR) and thus present fascinating new directions for research and applications with in vivo MR imaging and spectroscopy (MRI/S). Hyperpolarized 13C MRI/S, in particular, enables real-time non-invasive assessment of metabolic processes and holds great promise for a diverse range of clinical applications spanning fields like oncology, neurology, and cardiology, with a potential for improving early diagnosis of disease, patient stratification, and therapy response assessment. Despite its potential, technical challenges remain for achieving clinical translation. This paper provides an overview of the discussions that took place at the international workshop "New Horizons in Hyperpolarized 13C MRI," in March 2023 at the Bavarian Academy of Sciences and Humanities, Munich, Germany. The workshop covered new developments, as well as future directions, in topics including polarization techniques (particularly focusing on parahydrogen-based methods), novel probes, considerations related to data acquisition and analysis, and emerging clinical applications in oncology and other fields.

Keywords

Consensus, Hyperpolarized 13C, Metabolism, Metabolic imaging, MR spectroscopy, MRI

Comments

PMID: 38147265