Faculty, Staff and Student Publications
Publication Date
5-11-2023
Journal
Brazilian Journal of Psychiatry
Abstract
OBJECTIVES: Bipolar disorder type 1 (BD1) and behavioral-variant frontotemporal dementia (bvFTD) share similar behavioral and cognitive symptoms, rendering the differential diagnosis between them a clinical challenge. We investigated the accuracy of social cognition (SC) measures to differentiate bvFTD from BD.
METHODS: We included three groups of participants: early-onset BD1 (in remission, n=20), bvFTD (n=18), and cognitively healthy controls (HC) (n=40), matched for age, schooling, and sex. All participants underwent cognitive assessment, including the Facial Emotion Recognition (FER) and Modified Faux-Pas (mFP) tests, which assess mentalizing.
RESULTS: Compared to HC, BD1 and bvFTD patients underperformed on both SC measures. BD1 and bvFTD did not differ regarding FER or mFP total scores, although patients with bvFTD had significantly higher difficulties than those in the BD1 group to detect social faux-pas (p < 0.001, d = 1.35).
CONCLUSION: BD1 and bvFTD share deficits in the core SC functions. These findings should be considered in the development of tasks aiming to improve clinical differentiation between the two disorders.
Keywords
Humans, Bipolar Disorder, Frontotemporal Dementia, Social Cognition, Neuropsychological Tests, Cognition, Alzheimer Disease, Dementia, cognitive impairment, executive functioning, mania, mood disorder
DOI
10.47626/1516-4446-2022-2935
PMID
36749822
PMCID
PMC10154010
PubMedCentral® Posted Date
April 2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Mental and Social Health Commons, Oncology Commons, Psychiatry and Psychology Commons
Comments
PMID: 36749822