Student and Faculty Publications

Publication Date

8-4-2023

Journal

Nature Communications

Abstract

The SWI/SNF ATP-dependent chromatin remodeler is a master regulator of the epigenome, controlling pluripotency and differentiation. Towards the C-terminus of the catalytic subunit of SWI/SNF is a motif called the AT-hook that is evolutionary conserved. The AT-hook is present in many chromatin modifiers and generally thought to help anchor them to DNA. We observe however that the AT-hook regulates the intrinsic DNA-stimulated ATPase activity aside from promoting SWI/SNF recruitment to DNA or nucleosomes by increasing the reaction velocity a factor of 13 with no accompanying change in substrate affinity (K

Keywords

Animals, Mice, Transcription Factors, Saccharomyces cerevisiae, Cell Lineage, Chromatin, Nucleosomes, DNA, Adenosine Triphosphate

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