Aneuploidy and Complex Genomic Rearrangements in Cancer Evolution

Authors

Toby M Baker
Sara Waise
Maxime Tarabichi
Peter Van Loo

Publication Date

2-1-2024

Journal

Nature Cancer

Abstract

Mutational processes that alter large genomic regions occur frequently in developing tumors. They range from simple copy number gains and losses to the shattering and reassembly of entire chromosomes. These catastrophic events, such as chromothripsis, chromoplexy and the formation of extrachromosomal DNA, affect the expression of many genes and therefore have a substantial effect on the fitness of the cells in which they arise. In this review, we cover large genomic alterations, the mechanisms that cause them and their effect on tumor development and evolution.

Keywords

Humans, Chromosome Aberrations, Neoplasms, Genome, Aneuploidy, Genomics

Comments

Associated Data

PMID: 38286829

DOI

10.1038/s43018-023-00711-y

PMID

38286829

PMCID

PMC7616040

PubMedCentral® Posted Date

May 2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes