Blastoid and Pleomorphic Mantle Cell Lymphoma Demonstrate Distinct Clinicopathologic and Genetic Features

Authors

Mahsa Khanlari
Huan Mo
Do Hwan Kim
Ali Sakhdari
Ken H Young
Preetesh Jain
Michael Wang
Shaoying Li
Rashmi Kanagal-Shamanna
Roberto N Miranda
Francisco Vega
L Jeffrey Medeiros
Chi Young Ok

Publication Date

8-1-2023

Journal

The American Journal of Surgical Pathology

Abstract

The blastoid (B) and pleomorphic (P) variants of mantle cell lymphoma (MCL) are associated with aggressive clinical behavior. In this study, we collected 102 cases of B-MCL and P-MCL from untreated patients. We reviewed clinical data, analyzed morphologic features using an image analysis tool (ImageJ) and we assessed mutational and gene expression profiles. The chromatin pattern of lymphoma cells was assessed quantitatively by the pixel value. Cases of B-MCL showed a greater median pixel value with lower variation compared with P-MCL, indicating a homogeneously euchromatin-rich pattern in B-MCL. In addition, the Feret diameter of the nuclei was significantly smaller (median 6.92 vs. 8.49 µm per nucleus, P

Keywords

Adult, Humans, Chromatin, Ki-67 Antigen, Lymphoma, Mantle-Cell, Mutation, mantle cell lymphoma, blastoid, pleomorphic, hybrid, mutation, gene expression profile, gene set enrichment assay

Comments

PMID: 37288826