Staphylococcus aureus Breast Implant Infection Isolates Display Recalcitrance to Antibiotic Pocket Irrigants

Authors

Jesus M Duran Ramirez
Jana Gomez
Blake M Hanson
Taha Isa
Terence M Myckatyn
Jennifer N Walker

Publication Date

2-14-2023

Journal

Microbiology Spectrum

Abstract

Breast implant-associated infections (BIAIs) are the primary complication following placement of breast prostheses in breast cancer reconstruction. Given the prevalence of breast cancer, reconstructive failure due to infection results in significant patient distress and health care expenditures. Thus, effective BIAI prevention strategies are urgently needed. This study tests the efficacy of one infection prevention strategy: the use of a triple antibiotic pocket irrigant (TAPI) against Staphylococcus aureus, the most common cause of BIAIs. TAPI, which consists of 50,000 U bacitracin, 1 g cefazolin, and 80 mg gentamicin diluted in 500 mL of saline, is used to irrigate the breast implant pocket during surgery. We used

Keywords

Animals, Mice, Anti-Bacterial Agents, Staphylococcus aureus, Cefazolin, Breast Implants, Bacitracin, Mastectomy, Staphylococcal Infections, Polymyxin B, Gentamicins, Microbial Sensitivity Tests

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Associated Data

PMID: 36507629