Immunological Monitoring in Hepatitis C Virus Controlled Human Infection Model

Authors

Naglaa H Shoukry
Andrea L Cox
Christopher M Walker

Publication Date

8-14-2023

Journal

Clinical Infectious Diseases

Abstract

Controlled human infection model trials for hepatitis C virus represent an important opportunity to identify correlates of protective immunity against a well-characterized inoculum of hepatitis C virus and how such responses are modified by vaccination. In this article, we discuss the approach to immunological monitoring during such trials, including a set of recommendations for optimal sampling schedule and preferred immunological assays to examine the different arms of the immune response. We recommend that this approach be adapted to different trial designs. Finally, we discuss how these studies can provide surrogate predictors of the success of candidate vaccines.

Keywords

Humans, Hepacivirus, Monitoring, Immunologic, Hepatitis C, Vaccination, hepatitis C virus, vaccine, controlled human infection, immune monitoring, T lymphocytes, antibodies, cytokines

Comments

PMID: 37579206

DOI

10.1093/cid/ciad359

PMID

37579206

PMCID

PMC10425133

PubMedCentral® Posted Date

August 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes