Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis and Regulates a Schizophrenia Susceptibility Gene Network within the Mouse Dentate Gyrus

Authors

Prithviraj Rajebhosale
Alice Jone
Kory R Johnson
Rohan Hofland
Camille Palarpalar
Samara Khan
Lorna W Role
David A Talmage

Publication Date

10-23-2024

Journal

The Journal of Neuroscience

Abstract

Neuregulin1 (Nrg1) signaling is critical for neuronal development and function from fate specification to synaptic plasticity. Type III Nrg1 is a synaptic protein which engages in bidirectional signaling with its receptor ErbB4. Forward signaling engages ErbB4 phosphorylation, whereas back signaling engages two known mechanisms: (1) local axonal PI3K-AKT signaling and (2) cleavage by γ-secretase resulting in cytosolic release of the intracellular domain (ICD), which can traffic to the nucleus (Bao et al., 2003; Hancock et al., 2008). To dissect the contribution of these alternate signaling strategies to neuronal development, we generated a transgenic mouse with a missense mutation (V

Keywords

Animals, Female, Male, Mice, Cell Nucleus, Dentate Gyrus, Gene Regulatory Networks, Genetic Predisposition to Disease, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Missense, Neural Stem Cells, Neuregulin-1, Neurogenesis, Schizophrenia, Signal Transduction

Comments

Associated Data

PMID: 39214704

DOI

10.1523/JNEUROSCI.0063-24.2024

PMID

39214704

PMCID

PMC11502234

PubMedCentral® Posted Date

August 2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes