Faculty, Staff and Student Publications
Publication Date
3-1-2023
Journal
Trends in Neurosciences
Abstract
Chronic pain caused by injury or disease of the nervous system (neuropathic pain) has been linked to persistent electrical hyperactivity of the sensory neurons (nociceptors) specialized to detect damaging stimuli and/or inflammation. This pain and hyperactivity are considered maladaptive because both can persist long after injured tissues have healed and inflammation has resolved. While the assumption of maladaptiveness is appropriate in many diseases, accumulating evidence from diverse species, including humans, challenges the assumption that neuropathic pain and persistent nociceptor hyperactivity are always maladaptive. We review studies indicating that persistent nociceptor hyperactivity has undergone evolutionary selection in widespread, albeit selected, animal groups as a physiological response that can increase survival long after bodily injury, using both highly conserved and divergent underlying mechanisms.
Keywords
Humans, Animals, Nociceptors, Sensory Receptor Cells, Neuralgia, Adaptation, Physiological, Aplysia, cephalopod, chronic pain, human, primary afferent neuron, spontaneous activity
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Neurosciences Commons, Oncology Commons
Comments
PMID: 36610893