Chronic Kidney Disease in Public Renal Practices in Queensland, Australia, 2011–2018

Authors

Wendy E Hoy
Zaimin Wang
Jianzhen Zhang
Vishal Diwan
Anne Cameron
Sree K Venuthurupalli
Robert G Fassett
Samuel Chan
Helen G Healy
Ken-Soon Tan
Richard Baer
Andrew J Mallett
Nicholas Gray
Murty Mantha
Roy Cherian
Clyson Mutatiri
Krishan Madhan
George Kan
Geoffrey Mitchell
Shahadat Hossain
Danielle Wu
Thin Han
Adrian Kark
Thomas Titus
Dwarakanatan Ranganathan
Ann Bonner
Sridevi Govindarajulu
NHMRC CKD.CRE and the CKD.QLD Collaborative

Publication Date

12-1-2022

Journal

Nephrology

Abstract

AIM: To describe adults with (non-dialysis) chronic kidney disease (CKD) in nine public renal practice sites in the Australian state of Queensland.

METHODS: 7,060 persons were recruited to a CKD Registry in May 2011 and until start of kidney replacement therapy (KRT), death without KRT or June 2018, for a median period of 3.4 years.

RESULTS: The cohort comprised 7,060 persons, 52% males, with a median age of 68 yr; 85% had CKD stages 3A to 5, 45.4% were diabetic, 24.6% had diabetic nephropathy, and 51.7% were obese. Younger persons mostly had glomerulonephritis or genetic renal disease, while older persons mostly had diabetic nephropathy, renovascular disease and multiple diagnoses. Proportions of specific renal diagnoses varied >2-fold across sites. Over the first year, eGFR fell in 24% but was stable or improved in 76%. Over follow up, 10% started KRT, at a median age of 62 yr, most with CKD stages 4 and 5 at consent, while 18.8% died without KRT, at a median age of 80 yr. Indigenous people were younger at consent and more often had diabetes and diabetic kidney disease and had higher incidence rates of KRT.

CONCLUSION: The spectrum of characteristics in CKD patients in renal practices is much broader than represented by the minority who ultimately start KRT. Variation in CKD by causes, age, site and Indigenous status, the prevalence of obesity, relative stability of kidney function in many persons over the short term, and differences between those who KRT and die without KRT are all important to explore.

Keywords

Adult, Male, Humans, Aged, Aged, 80 and over, Female, Queensland, Renal Dialysis, Diabetic Nephropathies, Australia, Renal Insufficiency, Chronic, Obesity, Kidney, chronic kidney disease (CKD), epidemiology, indigenous, kidney replacement therapy (KRT), obesity, progression

Comments

PMID: 36161428