Plumbing Mysterious RNAs in “Dark Genome” for the Conquest of Human Diseases

Authors

Lisa A Huang
Chunru Lin
Liuqing Yang

Publication Date

6-7-2023

Journal

Molecular Therapy

Abstract

Next-generation sequencing has revealed that less than 2% of transcribed genes are translated into proteins, with a large portion transcribed into noncoding RNAs (ncRNAs). Among these, long noncoding RNAs (lncRNAs) represent the largest group and are pervasively transcribed throughout the genome. Dysfunctions in lncRNAs have been found in various diseases, highlighting their potential as therapeutic, diagnostic, and prognostic targets. However, challenges, such as unknown molecular mechanisms and nonspecific immune responses, and issues of drug specificity and delivery present obstacles in translating lncRNAs into clinical applications. In this review, we summarize recent publications that have explored lncRNA functions in human diseases. We also discuss challenges and future directions for developing lncRNA treatments, aiming to bridge the gap between functional studies and clinical potential and inspire further exploration in the field.

Keywords

Humans, RNA, Long Noncoding, Sanitary Engineering, RNA, Untranslated

Comments

PMID: 37165619

DOI

10.1016/j.ymthe.2023.05.003

PMID

37165619

PMCID

PMC10278048

PubMedCentral® Posted Date

May 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes