Self-Assembling Peptides As Immunomodulatory Biomaterials

Authors

Andrea Hernandez
Jeffrey D Hartgerink
Simon Young

Publication Date

1-1-2023

Journal

Frontiers in Bioengineering and Biotechnology

Abstract

Self-assembling peptides are a type of biomaterial rapidly emerging in the fields of biomedicine and material sciences due to their promise in biocompatibility and effectiveness at controlled release. These self-assembling peptides can form diverse nanostructures in response to molecular interactions, making them versatile materials. Once assembled, the peptides can mimic biological functions and provide a combinatorial delivery of therapeutics such as cytokines and drugs. These self-assembling peptides are showing success in biomedical settings yet face unique challenges that must be addressed to be widely applied in the clinic. Herein, we describe self-assembling peptides' characteristics and current applications in immunomodulatory therapeutics.

Keywords

biomaterials, self-assembling peptides (SAP), cancer, immunotherapy, localized delivery

Comments

PMID: 36937769

DOI

10.3389/fbioe.2023.1139782

PMID

36937769

PMCID

PMC10014862

PubMedCentral® Posted Date

March 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes