Convergent Deployment of Ancestral Functions During the Evolution of Mammalian Flight Membranes

Authors

Charles Y Feigin
Jorge A Moreno
Raul Ramos
Sarah A Mereby
Ares Alivisatos
Wei Wang
Renée van Amerongen
Jasmin Camacho
John J Rasweiler
Richard R Behringer
Bruce Ostrow
Maksim V Plikus
Ricardo Mallarino

Publication Date

3-24-2023

Journal

Science Advances

Abstract

Lateral flight membranes, or patagia, have evolved repeatedly in diverse mammalian lineages. While little is known about patagium development, its recurrent evolution may suggest a shared molecular basis. By combining transcriptomics, developmental experiments, and mouse transgenics, we demonstrate that lateral Wnt5a expression in the marsupial sugar glider (Petaurus breviceps) promotes the differentiation of its patagium primordium. We further show that this function of Wnt5a reprises ancestral roles in skin morphogenesis predating mammalian flight and has been convergently used during patagium evolution in eutherian bats. Moreover, we find that many genes involved in limb development have been redeployed during patagium outgrowth in both the sugar glider and bat. Together, our findings reveal that deeply conserved genetic toolkits contribute to the evolutionary transition to flight in mammals.

Keywords

Mice, Animals, Mammals, Marsupialia, Chiroptera, Organogenesis, Mice, Transgenic, Sugars, Biological Evolution

Comments

Supplementary Material

PMID: 36961889

DOI

10.1126/sciadv.ade7511

PMID

36961889

PMCID

PMC10038344

PubMedCentral® Posted Date

March 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes