A Crosstalk Between Gut and Brain in Sepsis-Induced Cognitive Decline\

Authors

Vijayasree V Giridharan
Jaqueline S Generoso
Leonardo Lence
Gabriela Candiotto
Emílio Streck
Fabricia Petronilho
Anilkumar Pillai
Tarek Sharshar
Felipe Dal-Pizzol
Tatiana Barichello

Publication Date

5-23-2022

Journal

Journal of Neuroinflammation

DOI

10.1186/s12974-022-02472-4

PMID

35606817

PMCID

PMC9125851

PubMedCentral® Posted Date

5-23-2022

PubMedCentral® Full Text Version

Post-print

Abstract

BACKGROUND: Sepsis is a potentially fatal disease characterized by acute organ failure that affects more than 30 million people worldwide. Inflammation is strongly associated with sepsis, and patients can experience impairments in memory, concentration, verbal fluency, and executive functioning after being discharged from the hospital. We hypothesize that sepsis disrupts the microbiota-gut-brain axis homeostasis triggering cognitive impairment. This immune activation persists during treatment, causing neurological dysfunction in sepsis survivors.

METHODS: To test our hypothesis, adult Wistar rats were subjected to cecal-ligation and perforation (CLP) or sham (non-CLP) surgeries. The animals were subjected to the [

RESULTS: Compared to the control group, the 24-h and 10-day CLP groups showed increased [

CONCLUSIONS: Since several pharmacological studies have failed to prevent cognitive impairment in sepsis survivors, a better understanding of the function of glial cells and gut microbiota can provide new avenues for treating sepsis patients.

Keywords

Animals, Brain, Brain-Gut Axis, Cognitive Dysfunction, Cytokines, Gastrointestinal Microbiome, Humans, Rats, Rats, Wistar, Sepsis

Published Open-Access

yes

Recommended Citation

Giridharan, Vijayasree V; Generoso, Jaqueline S; Lence, Leonardo; et al., "A Crosstalk Between Gut and Brain in Sepsis-Induced Cognitive Decline\" (2022). Faculty, Staff and Student Publications. 2571.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/2571