Comparative Molecular Genomic Analyses of a Spontaneous Rhesus Macaque Model of Mismatch Repair-Deficient Colorectal Cancer

Authors

Nejla Ozirmak Lermi
Stanton B Gray
Charles M Bowen
Laura Reyes-Uribe
Beth K Dray
Nan Deng
R Alan Harris
Muthuswamy Raveendran
Fernando Benavides
Carolyn L Hodo
Melissa W Taggart
Karen Colbert Maresso
Krishna M Sinha
Jeffrey Rogers
Eduardo Vilar

Publication Date

4-1-2022

Journal

PLoS Genetics

Abstract

Colorectal cancer (CRC) remains the third most common cancer in the US with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation of the MLH1 promoter. A cohort of rhesus macaques from our institution developed spontaneous mismatch repair deficient (MMRd) CRC with a notable fraction harboring a pathogenic germline mutation in MLH1 (c.1029C

Keywords

Animals, Colonic Neoplasms, Colorectal Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA Methylation, DNA Mismatch Repair, Genomics, Humans, Macaca mulatta, Mice, Microsatellite Instability, MutL Protein Homolog 1

DOI

10.1371/journal.pgen.1010163

PMID

35446842

PMCID

PMC9064097

PubMedCentral® Posted Date

4-21-2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes