Faculty, Staff and Student Publications
Publication Date
6-28-2022
Journal
mSystems
Abstract
Mexican Americans have a high prevalence of diabetes and burden of diabetes-related complications, highlighting the need for novel preventive strategies and noninvasive predictors of diabetes risk tailored to this population. Changes in the gut microbiome have the potential to predict diabetes. Here, we aimed to identify alterations in the gut microbiome associated with diabetes in the high-risk population of Mexican Americans in South Texas. Stool samples were collected from 216 subjects from the population-based Cameron County Hispanic Cohort. Among them, 75 had type 2 diabetes. Taxonomic and functional profiling of the stool samples were assessed by 16S and shotgun metagenomic sequencing, and the influence of genetic factors was explored. The gut microbiome of subjects with diabetes was enriched with proinflammatory Proteobacteria members (Enterobacteriaceae, Escherichia
Keywords
Humans, Butyrates, Diabetes Mellitus, Type 2, Enterobacteriaceae, Gastrointestinal Microbiome, Mexican Americans, Prospective Studies, Texas
DOI
10.1128/msystems.00033-22
PMID
35477306
PMCID
PMC9238400
PubMedCentral® Posted Date
4-28-2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons
