Neuronal Population Activity Dynamics Reveal a Low-Dimensional Signature of Operant Learning in Aplysia

Authors

Renan M Costa
Douglas A Baxter
John H Byrne

Publication Date

1-24-2022

Journal

Communications Biology

Abstract

Learning engages a high-dimensional neuronal population space spanning multiple brain regions. However, it remains unknown whether it is possible to identify a low-dimensional signature associated with operant conditioning, a ubiquitous form of learning in which animals learn from the consequences of behavior. Using single-neuron resolution voltage imaging, here we identify two low-dimensional motor modules in the neuronal population underlying Aplysia feeding. Our findings point to a temporal shift in module recruitment as the primary signature of operant learning. Our findings can help guide characterization of learning signatures in systems in which only a smaller fraction of the relevant neuronal population can be monitored.

Keywords

Animals, Aplysia, Conditioning, Operant, Neurons

DOI

10.1038/s42003-022-03044-1

PMID

35075264

PMCID

PMC8786933

PubMedCentral® Posted Date

1-24-2025

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes