Faculty, Staff and Student Publications

Publication Date

7-2-2024

Journal

Nature Communications

DOI

10.1038/s41467-024-49439-y

PMID

38956430

PMCID

PMC11220107

PubMedCentral® Posted Date

7-2-2024

PubMedCentral® Full Text Version

Post-print

Abstract

The biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized repositories. The ARRIVE guidelines outline documentation standards for laboratory animals in experiments, but genetic information is often incomplete. To remedy this, we propose the Laboratory Animal Genetic Reporting (LAG-R) framework. LAG-R aims to document animals' genetic makeup in scientific publications, providing essential details for replication and appropriate model use. While verifying complete genetic compositions may be impractical, better reporting and validation efforts enhance reliability of research. LAG-R standardization will bolster reproducibility, peer review, and overall scientific rigor.

Keywords

Animals, Animals, Laboratory, Guidelines as Topic, Reproducibility of Results, Research Design, Animal Experimentation, Biomedical Research, Eukaryote, Animal breeding, CRISPR-Cas9 genome editing, Sequencing

Published Open-Access

yes

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