Faculty, Staff and Student Publications
Publication Date
11-1-2022
Journal
International Journal of Molecular Sciences
DOI
10.3390/ijms232113334
PMID
36362132
PMCID
PMC9659249
PubMedCentral® Posted Date
11-1-2022
PubMedCentral® Full Text Version
Post-print
Abstract
Focal adhesion kinase (FAK) is a multifunctional protein involved in cellular communication, integrating and transducing extracellular signals from cell-surface membrane receptors. It plays a central role intracellularly and extracellularly within the tumor microenvironment. Perturbations in FAK signaling promote tumor occurrence and development, and studies have revealed its biological behavior in tumor cell proliferation, migration, and adhesion. Herein we provide an overview of the complex biology of the FAK family members and their context-dependent nature. Next, with a focus on cancer, we highlight the activities of FAK signaling in different types of cancer and how knowledge of them is being used for screening natural compounds used in herbal medicine to fight tumor development.
Keywords
Humans, Focal Adhesion Protein-Tyrosine Kinases, Herbal Medicine, Cell Movement, Focal Adhesion Kinase 1, Neoplasms, Signal Transduction, Phosphorylation, Cell Adhesion, Tumor Microenvironment
Published Open-Access
yes
Recommended Citation
Chen, Feiyu; Zhong, Zhangfeng; Zhang, Cheng; et al., "Potential Focal Adhesion Kinase Inhibitors in Management of Cancer: Therapeutic Opportunities from Herbal Medicine" (2022). Faculty, Staff and Student Publications. 2761.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/2761
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