Mouse Models of Chronic Lymphocytic Leukemia and Richter Transformation: What We Have Learnt and What We Are Missing

Authors

Maria Teresa Sabrina Bertilaccio
Shih-Shih Chen

Publication Date

1-1-2024

Journal

Frontiers in Immunology

Abstract

Although the chronic lymphocytic leukemia (CLL) treatment landscape has changed dramatically, unmet clinical needs are emerging, as CLL in many patients does not respond, becomes resistant to treatment, relapses during treatment, or transforms into Richter. In the majority of cases, transformation evolves the original leukemia clone into a diffuse large B-cell lymphoma (DLBCL). Richter transformation (RT) represents a dreadful clinical challenge with limited therapeutic opportunities and scarce preclinical tools. CLL cells are well known to highly depend on survival signals provided by the tumor microenvironment (TME). These signals enhance the frequency of immunosuppressive cells with protumor function, including regulatory CD4

Keywords

CLL, Richter transformation, mouse model, tumor microenvironment, CRISPR

Comments

PMID: 38903501