Faculty, Staff and Student Publications
Publication Date
11-1-2007
Journal
Radiotherapy & Oncology
Abstract
PURPOSE: To determine whether a 3-mm isotropic target margin adequately covers the prostate and seminal vesicles (SVs) during administration of an intensity-modulated radiation therapy (IMRT) treatment fraction, assuming that daily image-guided setup is performed just before each fraction.
MATERIALS AND METHODS: In-room computed tomographic (CT) scans were acquired immediately before and after a daily treatment fraction in 46 patients with prostate cancer. An eight-field IMRT plan was designed using the pre-fraction CT with a 3-mm margin and subsequently recalculated on the post-fraction CT. For convenience of comparison, dose plans were scaled to full course of treatment (75.6 Gy). Dose coverage was assessed on the post-treatment CT image set.
RESULTS: During one treatment fraction (21.4+/-5.5 min), there were reductions in the volumes of the prostate and SVs receiving the prescribed dose (median reduction 0.1% and 1.0%, respectively, p
CONCLUSIONS: The 3-mm intrafractional margin was adequate for prostate dose coverage. However, a significant subset of patients lost SV dose coverage. The rectal volume change significantly affected SV dose coverage. For advanced-stage prostate cancers, we recommend to use larger margins or improve organ immobilization (such as with a rectal balloon) to ensure SV coverage.
Keywords
Humans, Male, Prostatic Neoplasms, Radiotherapy Dosage, Radiotherapy, Intensity-Modulated, Seminal Vesicles, Tomography, X-Ray Computed
DOI
10.1016/j.radonc.2007.08.008
PMID
17892900
PMCID
PMC2759187
PubMedCentral® Posted Date
October 2009
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
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