Faculty, Staff and Student Publications
Publication Date
4-8-2024
Journal
Cancer Cell
DOI
10.1016/j.ccell.2024.03.011
PMID
38593779
Abstract
In cancer treatment, the recurrent challenge of inducing apoptosis through conventional therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to explore alternative cell death pathways. Ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal accumulation of lipid peroxides on cellular membranes, has emerged as one such promising frontier in oncology. Induction of ferroptosis not only suppresses tumor growth but also holds potential for augmenting immunotherapy responses and surmounting resistance to existing cancer therapies. This review navigates the role of ferroptosis in tumor suppression. Furthermore, we delve into the complex role of ferroptosis within the tumor microenvironment and its interplay with antitumor immunity, offering insights into the prospect of targeting ferroptosis as a strategic approach in cancer therapy.
Keywords
Humans, Ferroptosis, Tumor Microenvironment, Neoplasms, Immunotherapy, Medical Oncology
Published Open-Access
yes
Recommended Citation
Guang Lei, Li Zhuang, and Boyi Gan, "The Roles of Ferroptosis in Cancer: Tumor Suppression, Tumor Microenvironment, and Therapeutic Interventions" (2024). Faculty, Staff and Student Publications. 3163.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/3163
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Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons