Publication Date
10-1-2022
Journal
Nature Medicine
Abstract
Trogocytosis is an active process that transfers surface material from targeted to effector cells. Using multiple in vivo tumor models and clinical data, we report that chimeric antigen receptor (CAR) activation in natural killer (NK) cells promoted transfer of the CAR cognate antigen from tumor to NK cells, resulting in (1) lower tumor antigen density, thus impairing the ability of CAR-NK cells to engage with their target, and (2) induced self-recognition and continuous CAR-mediated engagement, resulting in fratricide of trogocytic antigen-expressing NK cells (NK
Keywords
Antigens, Neoplasm, Cell Line, Tumor, Immunotherapy, Adoptive, Killer Cells, Natural, Receptors, Chimeric Antigen, Trogocytosis, Tumor Escape
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons
Comments
This article has been corrected. See Nat Med. 2024 January 05; : .
Supplementary Materials
PMID: 36175679