Faculty, Staff and Student Publications
Publication Date
10-1-2022
Journal
Nature Medicine
DOI
10.1038/s41591-022-02003-x
PMID
36175679
PMCID
PMC9942695
PubMedCentral® Posted Date
4-1-2023
PubMedCentral® Full Text Version
Author MSS
Abstract
Trogocytosis is an active process that transfers surface material from targeted to effector cells. Using multiple in vivo tumor models and clinical data, we report that chimeric antigen receptor (CAR) activation in natural killer (NK) cells promoted transfer of the CAR cognate antigen from tumor to NK cells, resulting in (1) lower tumor antigen density, thus impairing the ability of CAR-NK cells to engage with their target, and (2) induced self-recognition and continuous CAR-mediated engagement, resulting in fratricide of trogocytic antigen-expressing NK cells (NK
Keywords
Antigens, Neoplasm, Cell Line, Tumor, Immunotherapy, Adoptive, Killer Cells, Natural, Receptors, Chimeric Antigen, Trogocytosis, Tumor Escape
Published Open-Access
yes
Recommended Citation
Li, Ye; Basar, Rafet; Wang, Guohui; et al., "KIR-Based Inhibitory CARs Overcome CAR-NK Cell Trogocytosis-Mediated Fratricide and Tumor Escape" (2022). Faculty, Staff and Student Publications. 322.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/322
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