Faculty, Staff and Student Publications

Publication Date

10-1-2022

Journal

Nature Medicine

Abstract

Trogocytosis is an active process that transfers surface material from targeted to effector cells. Using multiple in vivo tumor models and clinical data, we report that chimeric antigen receptor (CAR) activation in natural killer (NK) cells promoted transfer of the CAR cognate antigen from tumor to NK cells, resulting in (1) lower tumor antigen density, thus impairing the ability of CAR-NK cells to engage with their target, and (2) induced self-recognition and continuous CAR-mediated engagement, resulting in fratricide of trogocytic antigen-expressing NK cells (NK

Keywords

Antigens, Neoplasm, Cell Line, Tumor, Immunotherapy, Adoptive, Killer Cells, Natural, Receptors, Chimeric Antigen, Trogocytosis, Tumor Escape

Comments

This article has been corrected. See Nat Med. 2024 January 05; : .

Supplementary Materials

PMID: 36175679

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